Circa 1966 - The Amazing Spider-Man #33

You’ve seen the gif now read the comic. In this now famous Spidey issue, Spider-Man attempts to find the ISO-36 serum that may provide a cure for Aunt May. But from whose hands must he acquire this unique formula? Peter must make some difficult choices to save the ones he loves. At long last ASM #33 has come to comiXology!

^{Above gif created by the totally awesome Kerry Callen.}